Inspector Diana Joseph and her team confiscate a massive amount of cocaine and arrest some of the members of the syndicate, including the head of the syndicate "Sika Gang", Nithari, whose identity they do not know of. This enrages Nithari's brother, Ashwathama 'Ashu', who declares a bounty against the 5 cops and to retrieve the consignment. He also poisons the food and drinks of the cops at the retirement party of Diana's superior, thanks to information provided by the corrupt NCB cop, Devraj Subramaniam. Diana, who avoided the food and drinks, as she was under medication, convinces Bholaa, a recently released prisoner, to drive the cops to the nearest hospital, 80 kilometers away, in exchange of meeting his daughter, Jyothi. Bholaa reluctantly agrees and a race against time begins to save the cops, whilst dealing Ashu and his gang.